NOTICs

Monkeypox Cases Spreading In Europe, North America

NOTIC Id	Date	Scope	Type	Severity	Subject	summary
60b5febe81f88d2	01/06/2021	Asia	Warning	Medium	COVID-19 associated mucormycosis / Amphotericin B shortages	Numerous cases of COVID-19 associated mucormycosis have been reported in several countries in South Asia. In India, out of a total of 5424 cases, 4556 patients have a history of COVID-19 infection, with 55% of the patients having diabetes. Currently a global shortage of Amphotericin B to treat these patients is occuring. It is recommended to make mucormicosis a notifiable disease, explore alternatives to Amphotericin B during shortages, and judicial use of glucocorticoid therapies for managing COVID-19 patients.
60aa2a3f8b85dae	24/05/2021	Global	Recommendation	None	Change in diagnostic tests and surveillance of Bordetella species	Bordetella holmesii, causes symptoms similar to pertussis. Bordetella holmesii, first described in 1995, is believed to cause both invasive infections (bacteraemia, meningitis, endocarditis, pericarditis, pneumonia, and arthritis) and pertussis-like symptoms. Infection with B holmesii is frequently misidentified as being with B pertussis, the cause of whooping cough. Current PCR tests are frequently not specific to Bordetella holmesi. While no fatal cases of B holmesii have been reported, associated invasive infections can cause substantial morbidities, even in previously healthy individuals. Moreover, antimicrobial treatment can be problematic because B holmesii’s susceptibility to macrolides and third-generation cephalosporins is lower than would be expected. B holmesii’s adaptation to human beings is continuing, and virulence might increase, causing the need for better diagnostic assays and epidemiological surveillance.
607866fcc0767c7	05/04/2021	Global	Recommendation	None	Altering vaccination technique (viral vector vaccines) / blood clots and thrombocytopenia	Recommendation to alter IM vaccine procedures with modified viruses to include aspiration in order to limit adverse immunologic reactions.
607882e534071fc	01/04/2021	Global	Warning	Low	Control measures - highly pathogenic avian influenza (HPAI) circulation	Due to the continued presence of HPAI A viruses in wild birds and the environment, there is a risk of avian influenza incursions with the potential for human infections. Six different genotypes were identified to date in Europe and Russia, suggesting a high propensity of these viruses to undergo multiple re-assortment events. Seven cases due to A(H5N8) HPAI virus have been reported from Russia, all were poultry workers with mild or no symptoms. Five human cases due to A(H5N6) HPAI and 10 cases due to A(H9N2) LPAI viruses have been reported from China.
60787f495298166	01/03/2021	East Africa	Humanitarian aid	Medium	Urgent aid required to combat malaria in Madagascar	Madagascar is facing a surge of malaria related deaths. Urgent aid is needed. Shortage of malaria tests, antimalarial medicines and bed-nets.
NOTIC Id	Date	Scope	Type	Severity	Subject	summary

NOTIC Id

Date

Scope

Type

Severity

Subject

summary

Details

60b5febe81f88d2

01/06/2021

Asia

Warning

Medium

COVID-19 associated mucormycosis / Amphotericin B shortages

Numerous cases of COVID-19 associated mucormycosis have been reported in several countries in South Asia. In India, out of a total of 5424 cases, 4556 patients have a history of COVID-19 infection, with 55% of the patients having diabetes. Currently a global shortage of Amphotericin B to treat these patients is occuring. It is recommended to make mucormicosis a notifiable disease, explore alternatives to Amphotericin B during shortages, and judicial use of glucocorticoid therapies for managing COVID-19 patients.

60aa2a3f8b85dae

24/05/2021

Global

Recommendation

None

Change in diagnostic tests and surveillance of Bordetella species

Bordetella holmesii, causes symptoms similar to pertussis. Bordetella holmesii, first described in 1995, is believed to cause both invasive infections (bacteraemia, meningitis, endocarditis, pericarditis, pneumonia, and arthritis) and pertussis-like symptoms. Infection with B holmesii is frequently misidentified as being with B pertussis, the cause of whooping cough. Current PCR tests are frequently not specific to Bordetella holmesi. While no fatal cases of B holmesii have been reported, associated invasive infections can cause substantial morbidities, even in previously healthy individuals. Moreover, antimicrobial treatment can be problematic because B holmesii’s susceptibility to macrolides and third-generation cephalosporins is lower than would be expected. B holmesii’s adaptation to human beings is continuing, and virulence might increase, causing the need for better diagnostic assays and epidemiological surveillance.

607866fcc0767c7

05/04/2021

Global

Recommendation

None

Altering vaccination technique (viral vector vaccines) / blood clots and thrombocytopenia

Recommendation to alter IM vaccine procedures with modified viruses to include aspiration in order to limit adverse immunologic reactions.

607882e534071fc

01/04/2021

Global

Warning

Low

Control measures - highly pathogenic avian influenza (HPAI) circulation

Due to the continued presence of HPAI A viruses in wild birds and the environment, there is a risk of avian influenza incursions with the potential for human infections. Six different genotypes were identified to date in Europe and Russia, suggesting a high propensity of these viruses to undergo multiple re-assortment events. Seven cases due to A(H5N8) HPAI virus have been reported from Russia, all were poultry workers with mild or no symptoms. Five human cases due to A(H5N6) HPAI and 10 cases due to A(H9N2) LPAI viruses have been reported from China.

60787f495298166

01/03/2021

East Africa

Humanitarian aid

Medium

Urgent aid required to combat malaria in Madagascar

Madagascar is facing a surge of malaria related deaths. Urgent aid is needed. Shortage of malaria tests, antimalarial medicines and bed-nets.

NOTIC Id

Date

Scope

Type

Severity

Subject

summary

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